MP 2.04.63 DNA-Based Testing for Adolescent Idiopathic Scoliosis
ثبت نشده
چکیده
The ScoliScoreTM AIS (adolescent idiopathic scoliosis) prognostic DNA-based test (Axial Biotech, Salt Lake City, UT) is a saliva-based genetic test designed to predict the risk of progression of scoliosis in patients with AIS. The test uses an algorithm incorporating results of testing for 53 single nucleotide polymorphisms (SNPs), along with the patient’s presenting spinal curve (Cobb angle) to generate a risk score (ranging from 1 to 200), which can be used qualitatively or quantitatively to predict the likelihood of spinal curve progression. The test is intended for white (Caucasian) patients with a primary diagnosis of AIS between the ages of 9 and 13 years-old with a mild scoliotic curve (defined as < 25o).
منابع مشابه
Evaluation of Patient Outcome and Satisfaction after Surgical Treatment of Adolescent Idiopathic Scoliosis Using Scoliosis Research Society-30
Background: Adolescent idiopathic scoliosis (AIS) may lead to physical and mental problems. It also can adversely affect patient satisfaction and the quality of life. In this study, we assessed the outcomes and satisfaction rate after surgical treatment of AIS using scoliosis research society-30 questionnaire (SRS-30). Methods: We enrolled 135 patients with AIS undergoing corrective surgery...
متن کاملComparison of Respiratory Muscle Electromyography between Adolescent Idiopathic Scoliosis and Healthy Subjects
Purpose: Scoliosis is one of the most common spinal deformities that affect chest wall mechanics. Scoliosis results in ventilator disorders and respiratory muscle weakness. However, the mechanism of these disorders is still unknown. The main objective of this study was to identify the intensity of respiratory muscles activity in patients with idiopathic scoliosis compare with healthy indi...
متن کاملGenetic Risk for Aortic Aneurysm in Adolescent Idiopathic Scoliosis.
BACKGROUND Scoliosis is a feature of several genetic disorders that are also associated with aortic aneurysm, including Marfan syndrome, Loeys-Dietz syndrome, and type-IV Ehlers-Danlos syndrome. Life-threatening complications of aortic aneurysm can be decreased through early diagnosis. Genetic screening for mutations in populations at risk, such as patients with adolescent idiopathic scoliosis,...
متن کاملClinical Assessment of Adolescent Idiopathic Scoliosis Pre- and Post-Surgical Intervention in a Division I Female College Gymnast: A Case Study
Adolescent idiopathic scoliosis is defined as a lateral and rotational curvature of the spine with an unknown origin. Scoliosis is diagnosed based on age of onset and clinical presentation. Physicians measure curve severity by Cobb’s angle, which is marked on an x-ray. Participation is sports, which require compressive and tensile forces on the spine increase risk of back-related injury, includ...
متن کاملAssessment of Coronal Radiographic Parameters of the Spine in the Treatment of Adolescent Idiopathic Scoliosis
Background: To determine the most important preoperative factors that affect postoperative coronal parameters of scoliotic curves. Methods: All Adolescent Idiopathic Scoliosis (AIS) patients included in the study were classified according to Lenke and King Classification. The fusion levels were selected according to the rigidity of the existing curves (correction less than 50%), tilt...
متن کامل